These patients often develop swollen joints and the excess fluid represents an attractive source to harvest and study the cells that cause damage within the diseased joint without damaging the joint tissue itself. The Epigenetics Research group used these cells to perform genome-wide profiling across more than 20,000 individual genes in these patients.
These important new data support the use of joint fluid as a readily available alternative to study the role of these changes in the onset of joint disease and in the clinical management of this condition.
The study was funded by the Haywood Rheumatism Research and Development Foundation, and was authored by John Glossop, Kim Haworth, Nicola Nixon, Jon Packham, Peter Dawes, Anthony Fryer, Derek Mattey and William Farrell (ISTM/Haywood Rheumatology Centre), together with Richard Emes, Professor of Bioinformatics at the University of Nottingham.
|Dr John Glossop|